Merck Held the “Innovation Day” in Shanghai for Start-up Empowerment and a Better Innovation Ecosystem in China
Tantti® Monolith has a unique global patent, we call it IMP method (In-Mold Polymerization) and we use In-Mold Polymerization to produce a highly connected honeycomb structure for the production of biological products and other related products. The process is expected to greatly break through the bottleneck of purification for macro molecules, especially accelerate the production of various biologic products such as protein, antibody analysis, exosome and viral particle purification, thereby effectively reducing the cost of protein drugs and vaccine production. In addition, this IMP technology can be used to adsorb and remove various trace substances, such as endotoxin, circulating tumor DNA, DNA impurities in the vaccine production process, host cell protein HCP, etc., for industrial application. From the laboratory research to the application of downstream purification and mass production process, tantti’s IMP technology is a very pioneering idea and create excellent product value for downstream purification materials. We believe the monolith of tannti can provide new solution for Unmet need in the analysis and purification market.
Tantti® SpherTantrix, with its unique 3D porous structure, is tailored to encourage fast formation of cell spheroids. It offers cost effective solutions in high-throughput drug/content screening, 3D tumor/organ engineering, cell-base diagnostics, and 3D cell culture research (e.g. cancer cell biology and stem cell biology). We have demonstrated its flexibility in anti-tumor drug screening using various tumor cell lines and uniform spheroid clusters were easily observed and consistent between wells. In addition, Tantti® SpherTantrix contains animal-component-free materials and has ultralow fluorescent background to meet your versatile research or development needs.
The UniTantrix™ microcarrier is a unique porous microporous microcarrier with high connectivity, uniform pores, and high surface area. It is manufactured from medical grade gelatin with high mechanical strength and thermal stability. When cells are cultured in the microcarrier, the high surface area provides more adhesion area for the cells and the large pore structure allows the cells to adhere to the external and internal surface. The microcarriers internal structure can serve as protection from shear stress-induced damages for the cells growing inside. The interconnected pores ensure that the growth environment of the cells inside the microcarrier is uniformly stabilized, increasing the activity and productivity of the cells. In addition, when harvesting the cells, the microcarriers can be dissolved with trypsin, and the recovery of viable cells can be almost 100%.
Tantti Laboratory Inc. has developed a patented technique to fabricate a biomaterial matrix with uniformly ordered pores. Such unique structure has demonstrated great promise in 3D cell culture bio-scaffolds and microcarriers, as well as in monolithic matrix for bioseparation of proteins and viruses.
Tantti Laboratory Inc. was founded in 2014 by eight distinguished professors in Taiwan with expertise in Chemical and Materials Engineering. Since its inception, the company has developed two platform technologies which use Microfluidics and In-mold polymerization to create highly ordered micro- and nano-porous biomaterials. Our technologies have been patented around the world (e.g. USA, Europe, Japan, Taiwan and China) and offer great flexibilities in biomaterials (e.g. collagen or animal-free), scaffold thickness, pore sizes, mechanical stiffness adjustments, and biodegradability, adapting to versatile cell expansion and bioseparation applications.