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Tantti Monolith

Tantti® Monolith has a unique global patent, we call it IMP method (In-Mold Polymerization) and we use In-Mold Polymerization to produce a highly connected honeycomb structure for the production of biological products and other related products. The process is expected to greatly break through the bottleneck of purification for macro molecules, especially accelerate the production of various biologic products such as protein, antibody analysis, exosome and viral particle purification, thereby effectively reducing the cost of protein drugs and vaccine production. In addition, this IMP technology can be used to adsorb and remove various trace substances, such as endotoxin, circulating tumor DNA, DNA impurities in the vaccine production process, host cell protein HCP, etc., for industrial application. From the laboratory research to the application of downstream purification and mass production process, tantti’s IMP technology is a very pioneering idea and create excellent product value for downstream purification materials. We believe the monolith of tannti can provide new solution for Unmet need in the analysis and purification market.

Request for samples
High-resolution separation with increased sample load.
High-resolution separation with increased sample load.
Good pH stability.
Good pH stability.
High operating flow rate due to low back pressure, Easy scale-up.
High operating flow rate due to low back pressure, Easy scale-up.
Rapid separation of large-scale bio molecules.
Rapid separation of large-scale bio molecules.
Desired surface chemistries for cinematographic applications.
Desired surface chemistries for cinematographic applications.
Containing controlled macro & inter pores , Mono dispersed pore size distribution, Uniform and consistent pore structure throughout.
Containing controlled macro & inter pores , Mono dispersed pore size distribution, Uniform and consistent pore structure throughout.

 

 What is a liquid chromatography column?

 

With the advancement of biotechnology, biopharmaceuticals have flourished in recent years, and the trend would greatly drive the growth of the analysis and downstream purification market of the pharmaceutical industry. In the market for analysis and purification, for the application of macromolecular drugs, the faster and more effective liquid chromatography column has become an important issue of the industry.

 

Liquid chromatography columns were used in a wide range of applications, including water purification, biopharmaceuticals, food ingredient analysis. The report ,"Case study on high-efficiency chromatography materials and application in biomedical separation and purification" point out that downstream separation and purification account about 50 to 80% cost of biopharmaceuticals, which is often the bottleneck of biopharmaceutical production, and with more increasing challenges with the biopharmaceutical separation and purification process, latest biotechnology applications are being applied. The innovation of chromatography materials and manufacturing method will bring new application opportunities for the liquid chromatography systems.

 

 

 

 

Applications of a monolithic column on liquid chromatography.

 

Traditional chromatography column is packed with uniform micro or nanospheres in the column so that when mobile phase and the target are flowing in the gap between the spheres (the stationary phase), the different interaction between the two phases will result in differences in residence time in the column. The disadvantage of the conventional chromatography column is too small gap between the balls, and the moving phase will cause very large backpressure, so the flow rate will be very slow. Therefore, the monolithic column is a very useful purification method in the downstream separation process. The monolithic column is different from the traditional packing column. The monolithic column has a whole piece of the connected substrate, and the internal random distributed channel is bigger than the traditional column, because of the larger channel, it will greatly improve operation speed and maintain lower backpressure, constant efficiency of analysis and purification. By some studies had shown that overall column purification speed is more than twice of the conventional column, and the purification performance can keep very consistent under high flow rate. It is especially suitable for protein, monoclonal antibody, and virus particles purification in biopharmaceuticals, this reason is monolithic column can offer large channels to allow macromolecule to pass quickly and maintaining excellent separation purpose at the same time.

 

 

Reference: The Emerging Generation of Chromatography Tools for Virus Purification

 

 

 

 

Introduction of Tantti® Monolith

 

Tantti Laboratory Inc. can synthesize a variety of uniform micro to nanoscale polymer spheres with different particle size and surface functionalization. By the powerful patented technologies, Tantti can make large volume column, with flat or cylindrical structures, and provide material and surface modification service according to market demand. Tantti was proud of the innovative technology and created a series of products, such as size-exclusion, ion-exchange, hydrophilicity, and affinity monolithic column. This highly connected honeycomb structure is suitable for the small-scale rapid analysis and large-scale purification of biopharmaceuticals in the international market.



 

 

 

 

 

 

 

 

 

 

 

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Tantti Monolith